Stefan Dukic, dr.

Postdoc

Senior onderzoeker Team Oorzaak & verloop

UMC Utrecht

Introduction

I am a postdoctoral research fellow and EEG project leader. My background is in biomedical/neural engineering, which I use to investigate EEG impairments in ALS disease using advanced signal analysis techniques. My research aims to identify and internationally validate biomarkers that can track disease progression and signal the onset of ALS, by using longitudinal data from patients and their asymptomatic family members. To this end, I employ EEG paradigms that capture motor and cognitive functions, as well as resting-state recordings. I also actively foster collaborations between EEG research and other research lines to better understand ALS from the complementary angles they offer. My long-term goal is to establish more precise clinical tools for early disease detection and monitoring.

Academic background

Bachelor: BSc Electrical and computer engineering – University of Novi Sad (Serbia) – 2014
Master study: MSc Biomedical engineering (Neural engineering) – University of Groningen (The Netherlands) and Trinity College Dublin (Ireland) – 2016
PhD project: ‘Mapping electroencephalographic changes in amyotrophic lateral sclerosis’ – Prof. Leonard H. van den Berg and Prof. Orla Hardiman – Utrecht University (The Netherlands) – 28 November 2023

Awards/grants

I have received the personal ALS Talent Fellowship (2022-2025) and a project grant (2022-2025) from Stichting ALS Nederland to work on EEG biomarkers in ALS and asymptomatic C9orf72 repeat expansion carriers. Additionally, I was awarded the ALS Canada Acceleration Grant (2022-2025) to investigate the relationship between EEG and MRI in ALS and C9orf72 repeat expansion. I am a co-applicant on grants with Trinity College Dublin (ALS Centre Dublin) from The Galen and Hilary Weston Foundation (2025-2028) and The ALS Association (2023-2026), which focus on validating our previous EEG findings.

My publications

Dukic, S., Fasano, A., Coffey, A., Buxó, T., McMackin, R., Chipika, R., Heverin, M., Bede, P., Muthuraman, M., Lowery, M., Carson, R. G., Hardiman, O., & Nasseroleslami, B. (2024). Electroencephalographic β‐band oscillations in the sensorimotor network reflect motor symptom severity in amyotrophic lateral sclerosis. European Journal Of Neurology, 31(4), e16201. https://doi.org/10.1111/ene.16201
https://doi.org/10.1111/ENE.16201
Dukic, S., Govaarts, R., Hillebrand, A., De Visser, M., Seeck, M., & McMackin, R. (2025). Novel approaches to EEG and MEG in motor neurone disease: IFCN Handbook Chapter. Clinical Neurophysiology Practice, 10, 301–315. https://doi.org/10.1016/j.cnp.2025.07.001
https://doi.org/10.1016/J.CNP.2025.07.001
Dukic, S., McMackin, R., Buxo, T., Fasano, A., Chipika, R., Pinto‐Grau, M., Costello, E., Schuster, C., Hammond, M., Heverin, M., Coffey, A., Broderick, M., Iyer, P. M., Mohr, K., Gavin, B., Pender, N., Bede, P., Muthuraman, M., Lalor, E. C., . . . Nasseroleslami, B. (2019). Patterned functional network disruption in amyotrophic lateral sclerosis. Human Brain Mapping, 40(16), 4827–4842. https://doi.org/10.1002/hbm.24740
https://doi.org/10.1002/hbm.24740
Dukic, S., McMackin, R., Costello, E., Metzger, M., Buxo, T., Fasano, A., Chipika, R., Pinto-Grau, M., Schuster, C., Hammond, M., Heverin, M., Coffey, A., Broderick, M., Iyer, P. M., Mohr, K., Gavin, B., McLaughlin, R., Pender, N., Bede, P., . . . Nasseroleslami, B. (2021). Resting-state EEG reveals four subphenotypes of amyotrophic lateral sclerosis. Brain, 145(2), 621–631. https://doi.org/10.1093/brain/awab322
https://doi.org/10.1093/BRAIN/AWAB322
Dukic, S., Van Veenhuijzen, K., Westeneng, H., McMackin, R., Van Eijk, R. P. A., Sleutjes, B. T. H. M., Nasseroleslami, B., Hardiman, O., & Van Den Berg, L. H. (2025). Altered EEG Response of the Parietal Network in Asymptomatic C9orf72 Carriers. Human Brain Mapping, 46(11), e70275. https://doi.org/10.1002/hbm.70275
https://doi.org/10.1002/HBM.70275
Metzger, M., Dukic, S., McMackin, R., Giglia, E., Mitchell, M., Bista, S., Costello, E., Peelo, C., Tadjine, Y., Sirenko, V., McManus, L., Buxo, T., Fasano, A., Chipika, R., Pinto-Grau, M., Schuster, C., Heverin, M., Coffey, A., Broderick, M., . . . Nasseroleslami, B. (2024). Distinct longitudinal changes in EEG measures reflecting functional network disruption in ALS cognitive phenotypes. Brain Topography, 38(1), 3. https://doi.org/10.1007/s10548-024-01078-8
https://doi.org/10.1007/S10548-024-01078-8
Metzger, M., Dukic, S., McMackin, R., Giglia, E., Mitchell, M., Bista, S., Costello, E., Peelo, C., Tadjine, Y., Sirenko, V., Plaitano, S., Coffey, A., McManus, L., Sharp, A. F., Mehra, P., Heverin, M., Bede, P., Muthuraman, M., Pender, N., . . . Nasseroleslami, B. (2023). Functional network dynamics revealed by EEG microstates reflect cognitive decline in amyotrophic lateral sclerosis. Human Brain Mapping, 45(1), e26536. https://doi.org/10.1002/hbm.26536
https://doi.org/10.1002/HBM.26536
Nasseroleslami, B., Dukic, S., Broderick, M., Mohr, K., Schuster, C., Gavin, B., McLaughlin, R., Heverin, M., Vajda, A., Iyer, P. M., Pender, N., Bede, P., Lalor, E. C., & Hardiman, O. (2017). Characteristic Increases in EEG Connectivity Correlate With Changes of Structural MRI in Amyotrophic Lateral Sclerosis. Cerebral Cortex, 29(1), 27–41. https://doi.org/10.1093/cercor/bhx301
https://doi.org/10.1093/cercor/bhx301
S. Dukic, P. M. Iyer, K. Mohr, O. Hardiman, E. C. Lalor and B. Nasseroleslami, "Estimation of coherence using the median is robust against EEG artefacts," 2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), Jeju, Korea (South), 2017, pp. 3949-3952, doi: 10.1109/EMBC.2017.8037720.
https://doi.org/10.1109/EMBC.2017.8037720
McMackin, R., Dukic, S., Costello, E., Pinto-Grau, M., Keenan, O., Fasano, A., Buxo, T., Heverin, M., Reilly, R., Pender, N., Hardiman, O., & Nasseroleslami, B. (2021). Sustained attention to response task-related beta oscillations relate to performance and provide a functional biomarker in ALS. Journal of Neural Engineering, 18(2), 026006. https://doi.org/10.1088/1741-2552/abd829
https://doi.org/10.1088/1741-2552/abd829
Roisin McMackin, Stefan Dukic, Emmet Costello, Marta Pinto-Grau, Antonio Fasano, Teresa Buxo, Mark Heverin, Richard Reilly, Muthuraman Muthuraman, Niall Pender, Orla Hardiman, Bahman Nasseroleslami, Localization of Brain Networks Engaged by the Sustained Attention to Response Task Provides Quantitative Markers of Executive Impairment in Amyotrophic Lateral Sclerosis, Cerebral Cortex, Volume 30, Issue 9, September 2020, Pages 4834–4846, https://doi.org/10.1093/cercor/bhaa076
https://doi.org/10.1093/cercor/bhaa076
Roisin McMackin, Stefan Dukic, Michael Broderick, Parameswaran M. Iyer, Marta Pinto-Grau, Kieran Mohr, Rangariroyashe Chipika, Amina Coffey, Teresa Buxo, Christina Schuster, Brighid Gavin, Mark Heverin, Peter Bede, Niall Pender, Edmund C. Lalor, Muthuraman Muthuraman, Orla Hardiman, Bahman Nasseroleslami, Dysfunction of attention switching networks in amyotrophic lateral sclerosis, NeuroImage: Clinical, Volume 22, 2019, 101707, ISSN 2213-1582, https://doi.org/10.1016/j.nicl.2019.101707.
https://doi.org/10.1016/j.nicl.2019.101707
Roisin McMackin, Stefan Dukic, Emmet Costello, Marta Pinto-Grau, Lara McManus, Michael Broderick, Rangariroyashe Chipika, Parameswaran M Iyer, Mark Heverin, Peter Bede, Muthuraman Muthuraman, Niall Pender, Orla Hardiman, Bahman Nasseroleslami, Cognitive network hyperactivation and motor cortex decline correlate with ALS prognosis, Neurobiology of Aging, Volume 104, 2021, Pages 57-70, ISSN 0197-4580, https://doi.org/10.1016/j.neurobiolaging.2021.03.002.
https://doi.org/10.1016/j.neurobiolaging.2021.03.002
Harold H.G. Tan, Abram D. Nitert, Kevin van Veenhuijzen, Stefan Dukic, Martine J.E. van Zandvoort, Jeroen Hendrikse, Michael A. van Es, Jan H. Veldink, Henk-Jan Westeneng, Leonard H. van den Berg, Neuroimaging correlates of domain-specific cognitive deficits in amyotrophic lateral sclerosis, NeuroImage: Clinical, Volume 45, 2025, 103749, ISSN 2213-1582, https://doi.org/10.1016/j.nicl.2025.103749
https://doi.org/10.1016/J.NICL.2025.103749

My clinical research projects

EEG-onderzoek (ALS-electrode)

Open voor deelname

Doorlopend

4 uur per bezoek

Oorzaak & verloop

Onderzoek naar de elektrische activiteit die afkomstig is uit de hersenen. Ons doel is om patronen te ontdekken in deze hersenactiviteit die karakteristiek zijn voor bepaalde (sub)groepen van ALS, PLS en PSMA.